NeuroMethylation Cream™ contains five essential nutrients that support the methylation processes associated with neurological and immune system function.* Neuro Methylation Cream™ is the foundation formula in NuMedica’s Advanced Neuro-Immune Program. This topical cream supports immune health and normal neurotransmitter production and metabolism.* The 5-MTHF in this formula is also known as the “L” form of 5-MTHF since it is the reduced form of folate.