The GI tract is a finely balanced environment where roughly 500 different strains of bacteria compete for space and nutrients. When there is a healthy balance (eubiosis), few symptoms exist. However, dysbiosis can occur when an overabundance of potentially harmful organisms prevail. The natural microflora balance can be upset by medications (such as antibiotics, oral contraceptives, etc.), excessive alcohol consumption, or poor dietary intake. Going beyond the threshold of traditional probiotic support, high-dose probiotics influence GI health and immunity in ways lower-dose probiotics cannot. Shown to activate over 1,700 genes involved in immune and inflammatory signaling, high-dose probiotics improve immune function, strengthen the gut-immune barrier, and promote inflammatory balance. Each Ortho Biotic 100 capsule provides six proven probiotic strains chosen for their ability to survive the harsh GI environment to deliver superior results.