Q. Is estrogen therapy linked to increased risk of heart attack and breast cancer?


No, estrogen therapy does not increase risk of disease, including heart attack and breast cancer. This false impression began in 1991, when the very controversial Women’s Health Initiative (WHI) was halted due to increased incidence of chronic disease among subjects. This study used the synthetic hormone, Prempro, and subjects of the study were and average age of 63 years. Meta-analyses following this study have shown that most of the subjects had pre-existing conditions that led to the development of disease during the study and that hormone therapy actually reduces the risk of cancer and other chronic diseases in women.

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