Hormonal adaptations make weight loss maintenance challenging

October 2011 - Scientists have discovered that battle to lose weight and keep it off is often hindered by hormones. A recent study published in the New England Journal of Medicine this week reveals that six hormones that play a role in regulating appetite are increased following weight loss.

The study, which was conducted in Australia, observed 50 overweight or obese dieters. Participants were required to consume no more than 550 calories per day with a goal weight loss of approximately 10 percent of their body weight. Hormone levels were measured prior to beginning the diet and then at various stages following the diet. Researchers required participants to follow a weight maintenance plan over the course of one year after completion of the initial study. During this time, dieters described increase hunger and cravings and researchers observed changes in hormones that influence satiety and appetite. According to the mechanisms of action, these changes would make it difficult for any dieter to maintain control of their appetite.

Scientists conclude that more studies must be done to fully understand these observations. One solution that has been suggested is to use drugs or hormone therapy to return hormones to normal levels following a successful diet.

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