Estrogen treatment may help reverse severe pulmonary hypertension

September 2011 - It’s been said that estrogen is good for your cardiovascular health, and a recent study reinforces this fact. Researchers from the David Geffen School of Medicine at UCLA have discovered that estrogen therapy helps to reverse severe pulmonary hypertension — and this benefit continues even after the therapy is stopped. Pulmonary hypertension describes an increasing rise in blood pressure in the artery that delivers blood from the right ventricle of the heart to the lungs. It progresses slowly and can lead to heart failure. Most treatment options currently in use only offer temporary improvement and, in advanced cases, lung transplants may be necessary.

Published in the American Journal of Respiratory and Critical Care Medicine, this study evaluated the effects of estrogen therapy on rats with severe pulmonary hypertension. Using low doses, the researchers were able to improve the volume of blood being pumped, correct lung weight and prevent the progression of right-ventricle heart failure. After only 10 days of treatment, the heart and lung function of the rats had nearly returned to a normal state — and this improvement continued after treatment was stopped. None of the treated rats died during the study, while only 25% of the untreated rats survived.

The study reveals just how potent estrogen therapy can be and promises beneficial effects even during low-dose, short-term estrogen therapy.

Read the full article: Estrogen treatment may help reverse severe pulmonary hypertension

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