Hormone Glossary
Post Menopause
All of the time in a woman’s life that take place after her last period ever, or more accurately, all of the time that follows the point when her ovaries become inactive. A woman who still has her uterus can be declared to be in post menopause once she has gone 12 full months with no flow at all, not even any spotting. Also seen as postmenopause or post-menopause.
Precursor
A chemical that can be converted by the body into another is a precursor of the latter chemical.
Pregnenolone
An unsaturated hydroxyl steroid that is formed by the oxidation of steroids (like cholesterol) and yields progesterone on dehydrogenation.
Premenstrual Syndrome (PMS)
A varied group of physical and psychological symptoms, including abdominal bloating, breast tenderness, headache, fatigue, irritability, anxiety and depression that occur from 2 to 7 days before the onset of menstruation and cease shortly after menses begins.
Prescription
A direction, usually written by the physician to the pharmacist for the preparation and use of a medicine or remedy.
Preventive Medicine
Measures taken to prevent illness or injury, rather than curing them. Preventive care may include examinations and screening tests tailored to an individual’s age, health and family history. Also called preventive care or preventative medicine.
Progesterone
A hormone that prepares the uterus for the fertilized ovum and maintains pregnancy.
Prolactin
A protein hormone produced by the pituitary gland of mammals that acts with other hormones to initiate the secretion of milk by the mammary glands. It also acts to maintain the corpus luteum of the ovary, which is the source of the female sex hormone progesterone. In males, high levels of prolactin can cause testosterone levels to decrease.
Prostate Specific Antigen (PSA)
A protein produced by the cells of the prostate gland. PSA is present in small quantities in the serum of normal men and is often elevated in the presence of prostate cancer and in other prostate disorders.
Receptors
A molecular structure or site on the surface or interior of a cell that binds with substances such as hormones.
Reverse Triiodothyronine (Reverse T3)
A molecule which is an isomer of triiodothyroniine and derived from thyroxine through the use of deiodinase. Blocks the action of T3.
Self-Injection
The act of injecting oneself with a drug or other substance.
Serotonin
Serotonin is an inhibitory neurotransmitter synthesized by enzymes that act on tryptophan and/or 5-HTP. Serotonin is stored in presynaptic vesicles and released to transmit electrochemical signals across the synapse. Extensive research has been conducted surrounding serotonin and acts as a target for symptoms like low mood, compulsions, anxiousness, and headaches. Serotonin acts, in most cases, as an inhibitory neurotransmitter and, like GABA, modulates neuron voltage potentials to inhibit glutamate activity and neurotransmitter firing. Serotonin neurons have large numbers of axons and are important in integrating neural circuits. This also provides an explanation for serotonin’s role in so many health concerns.
Serotonin
An inhibitory neurotransmitter required for sleep.
Serotonin Metabolite
5-Hydroxyindoleacetic acid (5-HIAA) is a major metabolite of serotonin, generated via a two step process, involving monoamine oxidase A (MAO-A) and aldehyde dehydrogenase. Measurement of 5-HIAA in combination with serotonin may offer insight into mechanisms underlying various clinical symptoms. The ratio of serotonin to 5-HIAA may be used to evaluate serotonin turnover and monoamine oxidase activity. Abnormal levels of 5-HIAA have been associated with depression, suicidal behaviors, aggression, chronic psychotropic medication use, and Parkinson’s Disease.
Serum
The clear yellowish fluid obtained upon separating whole blood into its solid and liquid components after it has been allowed to clot.
Sex Drive
A physiological need for sexual activity.
Sex Hormone
Any of a class of steroid hormones that regulate the growth and function of the reproductive organs or stimulate the development of the secondary sexual characteristics.
Sex Hormone-Binding Globulin (SHBG)
A glycoprotein produced by the liver cells that binds to sex hormones, specifically testosterone and estradiol.
Sleep Apnea
A temporary suspension of breathing occurring repeatedly during sleep that is caused especially by obstruction of the airway or a disturbance in the brain’s respiratory center and is associated especially with excessive daytime sleepiness.
Steroid Hormones
Any hormone containing the characteristic steroid ring complex; a term often associated with hormones such as progesterone, testosterone, estrogens, DHEA, and others.
Stress
Physical, mental, or emotional strain or tension; a specific response by the body to stimulus, as fear or pain, that disturbs or interferes with the normal physiological equilibrium of an organism.
Stressors
An agent, condition or other stimulus that causes stress to an organism.
Symptom(s)
A subjective indication of a disorder reported by an afflicted person rather than being observed by an examiner.
Synthetic Hormones
Hormones made from plant progesterone and animal chemicals that are bio-similar but not identical to the hormones your body uses. Generally, an extra covalent bond or molecules are added so that it can be patented or to alter it’s chemical properties or clinical effects. Being non-identical to the body may cause significant harmful side effects.
Taurine
Taurine is an inhibitory neurotransmitter involved in neuromodulatory and neuroprotective actions. Supplementing with taurine can have a specific effect on GABA function.There are two primary ways in which taurine affects GABA.; First, it can inhibit GABA transaminase, an enzyme that metabolizes GABA. This allows GABA to stay in the synaptic cleft longer to bind to the postsynaptic receptor. Second, taurine can bind to the GABAAreceptor mimicking the effects of GABA. By helping GABA function, taurine is an important neuromodulator for prevention of excitoxicity. Excitability occurs when glutamate binds to its receptor, in this case, the NMDA receptor. Once glutamate activates the NMDA receptor there is an increase in intracellular Ca++ causing depolarization or cell excitability. With glutamate release, there is also simultaneous GABA and taurine release. When the inhibitory neurotransmitters, GABA and taurine, activate the GABAA receptor, the result is an increase in intracellular Cl- ions. This results in hyperpolarization which reduces cell excitability. Thus, the overall effect of taurine supplementation is to support GABA function. The relevance of GABA support is to prevent overstimulation due to high levels of excitatory amino acids. Therefore, taurine and GABA constitute an important protective mechanism against excessive excitatory amino acids. Similarly, taurine is increased in response to the exposure of free radicals elucidating its neuroprotective actions. Exposure to free radicals increases glutamate excretion, further potentiation NMDA receptor activation. Taurine modulates this effect to prevent cell excitability by keeping the cell hyperpolarized. The supplementation of taurine can help alleviate some excitability issues associated with elevated excitatory amino acids as well as play a role in regulating the effect of free radicals.
Testosterone
A potent Androgenic hormone produced chiefly by the testes, which stimulates the development of male sex organs, secondary sexual traits and sperm.
Thyroid
The gland located in the center and anterior aspect of the neck responsible (amongst other things) for temperature regulation.
Thyroid Peroxidase (TPO)
An enzyme mainly expressed in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of T4, T3 and reverse T3.
Thyroid Stimulating Hormone (TSH)
A glycoprotein hormone secreted by the anterior portion of the pituitary gland that stimulates and regulates the activity of the thyroid gland. Also called thyrotropin.
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