Everything you wanted or needed to know about Resveratrol

Resveratrol was originally derived from the roots of the white hellebore in 1940, and the Japanese knotweed in 1963. However, it gained great popularity when it was found in red wine in 1992. Now, it is commonly known as “the red wine nutrient.” But, there’s more to resveratrol than red wine. Studies are taking place all over the world to see if the many benefits seen in animals can also be seen in humans. There is evidence that it may help to control blood sugar in diabetes. And, there are lots of other benefits that have been reported with Resveratrol that go beyond just things like weight loss and increased physical stamina. It's also helpful for increasing metabolism, improving the way your body deals with cholesterol and it may help protect you against cancer, especially of the skin and gastrointestinal tract.

The French Paradox

It is interesting to note that Resveratrol is made by the plants if they are being attacked by bacteria or fungi so it makes sense that they would serve as a source of protection. Back in 1819, an Irish physician by the name of Samuel Black discovered the phenomenon that was later coined by Dr. Serge Renaud as “The French Paradox.” The French Paradox is a term used to describe the unexpected correlation between France’s lower incidences of coronary disease despite a diet rich in saturated fats. Since the French are known for their ample consumption of wine, scientists looked for a link between Resveratrol and this puzzling anomaly. It remains a possibility as it was discovered that many regions in France produce wine with unusually high levels of Resveratrol.

Studies supporting red wine suggest antioxidants in red wine called polyphenols help protect the lining of blood vessels in your heart. Antioxidants work to reduce free-radical damage in the body. Free radicals produce oxidation within your cells and organs which can be very dangerous. An example of oxidation in our environment is rust on metal. This same process happens inside of us and antioxidants can help to reduce those effects. These antioxidants come in two main forms: flavonoids and nonflavonoids.

* Flavonoids. These antioxidants are found in a variety of foods, including oranges, grape juice, apples, onions, tea and cocoa. Other types of alcohol, such as white wine and beer, contain small amounts, too, but red wine has higher levels.

* Nonflavonoids. These antioxidants found in red wine have recently been of particular interest because they appear to help prevent arteries from becoming clogged with fat-laden placques. Resveratrol is the nonflavonoid that's received the most attention from researchers.

How does it work?

Although the exact mechanism is not completely known, it is thought to mimic the same biochemical pathways as calorie restriction. Through this process, the Resveratrol activates the gene Sirtuin1 (SIRT1) to improve the functioning of mitochondria. “Essentially, what happens is your body goes into what is commonly known as a “famine-related” survival mode, which then helps the body break down stored fat, deep within the white adipose tissue and burns it as fuel, promoting endurance and ultimately furthering longevity.” said Dr. Stanton. “It has been known for a long time by Anti-Aging specialists that, by restricting caloric intake, you can extend your lifespan, improve your fat and cholesterol metabolism, achieve a higher-functioning immune system and improve your cardiovascular health.”

What does this mean for the world of medicine?

Anti-aging industry leaders are currently conducting ground-breaking research and are likely to find some great results. Resveratrol may become one of the most well-rounded nutrients we know of – especially when you consider that it’s a nutrient produced to protect a plant that is under stress.